Sandbox Reserved 1647: Difference between revisions

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Here, we show that T-bet acts through enhancers to allow the recruitment of [[Mediator]] and [https://proteopedia.org/wiki/index.php/3mi9 P-TEFb] in the formation of the super elongation complex (SEC). Th1 genes are occupied by [[RNA Polymerase II]] in Thp cells, ~~while~~ T-bet-mediated ~~recruitment of P-TEFb and mediator. The~~ recruitment of P-TEFb and mediator activates transcriptional elongation ~~and~~ giving place to increased differentiation of Thp into Th1 <ref name="T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex">DOI 10.1016/j.celrep.2016.05.054</ref>.

Here, we show that T-bet acts through enhancers to allow the recruitment of [[Mediator]] and [https://proteopedia.org/wiki/index.php/3mi9 P-TEFb] in the formation of the super elongation complex (SEC). Th1 genes are occupied by [[RNA Polymerase II]] in Thp cells. In the meantime, T-bet-mediated recruitment of P-TEFb and mediator activates transcriptional elongation. This is giving place to increased differentiation of Thp into Th1 <ref name="T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex">DOI 10.1016/j.celrep.2016.05.054</ref>.

T-bet can also regulate Th1 cell differentiation by directly initiating gamma interferon (IFN-γ) transcription <ref name="The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.">DOI 10.1038/ni.1731</ref>and by suppressing Th2-specific transcription factor [https://proteopedia.org/wiki/index.php/3dfx GATA-3]<ref name="A novel transcription factor, T-bet, directs Th1 lineage commitment"> Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000). A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell, 100(6), 655–669. https://doi.org/10.1016/s0092-8674(00)80702-3</ref>. The T-bet induced expression of IFN-γ derives Th precursor cells to differentiate into Th1 effector cells.

Sandbox Reserved 1647: Difference between revisions

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Revision as of 16:56, 14 January 2022 view source Anne Larroche (talk \| contribs) 27 edits No edit summary ← Older edit		Revision as of 17:06, 14 January 2022 view source Anne Larroche (talk \| contribs) 27 edits No edit summary Newer edit →
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	Here, we show that T-bet acts through enhancers to allow the recruitment of [[Mediator]] and [https://proteopedia.org/wiki/index.php/3mi9 P-TEFb] in the formation of the super elongation complex (SEC). Th1 genes are occupied by [[RNA Polymerase II]] in Thp cells, ~~while~~ T-bet-mediated ~~recruitment of P-TEFb and mediator. The~~ recruitment of P-TEFb and mediator activates transcriptional elongation ~~and~~ giving place to increased differentiation of Thp into Th1 <ref name="T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex">DOI 10.1016/j.celrep.2016.05.054</ref>.		Here, we show that T-bet acts through enhancers to allow the recruitment of [[Mediator]] and [https://proteopedia.org/wiki/index.php/3mi9 P-TEFb] in the formation of the super elongation complex (SEC). Th1 genes are occupied by [[RNA Polymerase II]] in Thp cells. In the meantime, T-bet-mediated recruitment of P-TEFb and mediator activates transcriptional elongation. This is giving place to increased differentiation of Thp into Th1 <ref name="T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex">DOI 10.1016/j.celrep.2016.05.054</ref>.

	T-bet can also regulate Th1 cell differentiation by directly initiating gamma interferon (IFN-γ) transcription <ref name="The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.">DOI 10.1038/ni.1731</ref>and by suppressing Th2-specific transcription factor [https://proteopedia.org/wiki/index.php/3dfx GATA-3]<ref name="A novel transcription factor, T-bet, directs Th1 lineage commitment"> Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000). A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell, 100(6), 655–669. https://doi.org/10.1016/s0092-8674(00)80702-3</ref>. The T-bet induced expression of IFN-γ derives Th precursor cells to differentiate into Th1 effector cells.		T-bet can also regulate Th1 cell differentiation by directly initiating gamma interferon (IFN-γ) transcription <ref name="The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.">DOI 10.1038/ni.1731</ref>and by suppressing Th2-specific transcription factor [https://proteopedia.org/wiki/index.php/3dfx GATA-3]<ref name="A novel transcription factor, T-bet, directs Th1 lineage commitment"> Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000). A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell, 100(6), 655–669. https://doi.org/10.1016/s0092-8674(00)80702-3</ref>. The T-bet induced expression of IFN-γ derives Th precursor cells to differentiate into Th1 effector cells.