Sandbox reserved 1651: Difference between revisions

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Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of [http://en.wikipedia.org/wiki/Glycosyl] carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as[https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa].[1]

Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of [http://en.wikipedia.org/wiki/Glycosyl glycosyl] carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as[https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa].[1]

Sandbox reserved 1651: Difference between revisions

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Revision as of 08:07, 15 January 2022 view source Inès Ruxer (talk \| contribs) 48 edits No edit summary ← Older edit		Revision as of 08:12, 15 January 2022 view source Inès Ruxer (talk \| contribs) 48 edits No edit summary Newer edit →
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	<StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''>		<StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''>

	Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of [http://en.wikipedia.org/wiki/Glycosyl] carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as[https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa].[1]		Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of [http://en.wikipedia.org/wiki/Glycosyl glycosyl] carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as[https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa].[1]