Sandbox reserved 1651: Difference between revisions
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=== The active site organization === | === The active site organization === | ||
[https://en.wikipedia.org/wiki/Farnesyl_pyrophosphate Farnesyl diphosphate (FPP)] and [https://en.wikipedia.org/wiki/Magnesium#Chemical_properties Mg<sup>2+</sup>] are only detected in the active site of DHDDS and only the active site of DHDDS is required for the catalytic activity. NgBR induces an increase in the expression and activity of the complex, but itself has no catalytic activity. Indeed, NgBR active site does not have a visible substrate-binding cavity. The 3 β-strands and 2 α-helices are packed via hydrophobic interactions, so there is no cavity anymore and it is devoid of water. | [https://en.wikipedia.org/wiki/Farnesyl_pyrophosphate Farnesyl diphosphate (FPP)] and [https://en.wikipedia.org/wiki/Magnesium#Chemical_properties Mg<sup>2+</sup>] are only detected in the active site of DHDDS and only the active site of DHDDS is required for the catalytic activity. NgBR induces an increase in the expression and activity of the complex, but itself has no catalytic activity. Indeed, NgBR active site does not have a visible substrate-binding cavity. The 3 [https://en.wikipedia.org/wiki/Beta_sheet β-strands] and 2 [https://en.wikipedia.org/wiki/Alpha_helix α-helices] are packed via [https://en.wikipedia.org/wiki/Hydrophobic_effect hydrophobic interactions], so there is no cavity anymore and it is devoid of water. | ||
