Sandbox Reserved 1653: Difference between revisions
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Those mutations could provoke increases in permeability of cations in RBC by different mechanisms. It could induce mechanically activated currents that inactivate more slowly than wild-type currents. They could also affect the inactivation process by either destabilising the inactivated state or stabilising the channel in the open state. As a result, the open to inactivated state equilibrium shifts towards open. Na+ and Ca2+ ion influx consequently increase, and the intracellular K+ concentration decreases in a steady state. The evolution of Piezo1’s function steams from a change in its 3D structure. | Those mutations could provoke increases in permeability of cations in RBC by different mechanisms. It could induce mechanically activated currents that inactivate more slowly than wild-type currents. They could also affect the inactivation process by either destabilising the inactivated state or stabilising the channel in the open state. As a result, the open to inactivated state equilibrium shifts towards open. Na+ and Ca2+ ion influx consequently increase, and the intracellular K+ concentration decreases in a steady state. The evolution of Piezo1’s function steams from a change in its 3D structure. | ||
Lymphatic dysplasia is also a disease linked to loss of function mutations on Piezo1. The lymphatic system is independent from the vascular one, and its role is to transport antigens responsible | Lymphatic dysplasia is also a disease linked to loss of function mutations on Piezo1. The lymphatic system is independent from the vascular one, and its role is to transport antigens responsible for the immune response. If the interstitial fluid is not drained correctly back to the blood, it leads to local inflammation. The mutations on Piezo1 inactivate the channel gate and in this case the concentration of calcium is not increased. The protein isn’t sensitive to the pressure anymore. | ||
== Potential therapeutic target == | == Potential therapeutic target == | ||
