Sandbox Reserved 1653: Difference between revisions
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<references/><StructureSection load='5z10' size='350' side='right' caption='Structure of the mechanosensitive Piezo1 channel 1 from [http://www.rcsb.org/structure/5Z10 PBD]' scene=''> | <references/><StructureSection load='5z10' size='350' side='right' caption='Structure of the mechanosensitive Piezo1 channel 1 from [http://www.rcsb.org/structure/5Z10 PBD]' scene=''> | ||
Piezo1 proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo1 is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs.<ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 | Piezo1 proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo1 is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs.<ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 </ref> | ||
== Structure == | == Structure == | ||
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Cells are able to perceive the filling of the stomach or the bladder, blood flow and lungs inflation. | Cells are able to perceive the filling of the stomach or the bladder, blood flow and lungs inflation. | ||
Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo1 is involved in shear stress sensing in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [https://en.wikipedia.org/wiki/Hypertension hypertension]. It is also involved in the homeostasis of the volume of red blood cells. | Piezo1 is a sensor of mechanical forces in [https://en.wikipedia.org/wiki/Endothelium endothelial], urothelial and renal epithelial cells. For instance, Piezo1 is involved in shear stress sensing in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon [https://en.wikipedia.org/wiki/Hypertension hypertension]. It is also involved in the homeostasis of the volume of red blood cells. | ||
Piezo1 mediates cationic non-selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through Piezo1. | Piezo1 mediates cationic non-selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through Piezo1. | ||
However, Piezo1 is implicated in excitatory channels because cations can enter into the cells which leads to the membrane [https://en.wikipedia.org/wiki/Depolarization depolarisation] or [https://en.wikipedia.org/wiki/Calcium_signaling calcium-dependent signalling pathway] (if Ca2+ enters).<ref name="Adenosine"> DOI 10.3389/fphar.2019.01304 </ref> | However, Piezo1 is implicated in excitatory channels because cations can enter into the cells which leads to the membrane [https://en.wikipedia.org/wiki/Depolarization depolarisation] or [https://en.wikipedia.org/wiki/Calcium_signaling calcium-dependent signalling pathway] (if Ca2+ enters).<ref name="Adenosine"> DOI 10.3389/fphar.2019.01304 </ref> | ||
