Sandbox Reserved 1653: Difference between revisions
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The subcellular localisation of Piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, Piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | The subcellular localisation of Piezo1 is also determining. In static conditions, its repartition is even on the membrane, but when a mechanical stimulus arises, Piezo1 accumulates at the cell’s apical. This process characterises endothelial cells’ alignment toward frictional force. | ||
However, Piezo1 is also able to drive endothelial cells migration without shear stress, through endothelial [https://en.wikipedia.org/wiki/Nitric_oxide_synthasenitric oxide synthase], a protein with major roles in vascular biology.<ref name= "vascularisation"> DOI 10.1038/nature13701</ref> | However, Piezo1 is also able to drive endothelial cells migration without shear stress, through endothelial [https://en.wikipedia.org/wiki/Nitric_oxide_synthasenitric oxide synthase], a protein with major roles in vascular biology.<ref name= "vascularisation"> DOI 10.1038/nature13701</ref> | ||
== Diseases == | == Diseases == | ||
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Lymphatic dysplasia <ref name = "Lymphatic dysplasia"> DOI 10.1016/bs.ctm.2017.01.001 </ref> is also a disease linked to loss of function mutations on Piezo1. The [https://en.wikipedia.org/wiki/Lymphatic_system lymphatic system] is independent from the vascular one, and its role is to transport antigens responsible for the immune response. If the interstitial fluid is not drained correctly back to the blood, it leads to local inflammation. The mutations on Piezo1 inactivate the channel gate and in this case the concentration of calcium is not increased. The protein isn’t sensitive to the pressure anymore. | Lymphatic dysplasia <ref name = "Lymphatic dysplasia"> DOI 10.1016/bs.ctm.2017.01.001 </ref> is also a disease linked to loss of function mutations on Piezo1. The [https://en.wikipedia.org/wiki/Lymphatic_system lymphatic system] is independent from the vascular one, and its role is to transport antigens responsible for the immune response. If the interstitial fluid is not drained correctly back to the blood, it leads to local inflammation. The mutations on Piezo1 inactivate the channel gate and in this case the concentration of calcium is not increased. The protein isn’t sensitive to the pressure anymore. | ||
== Potential therapeutic target == | == Potential therapeutic target == | ||
