Sandbox Reserved 1656: Difference between revisions

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==Deubiquitinases==

'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes ~~exist in~~ humans, making it a very ~~diverse~~ [https://en.wikipedia.org/wiki/Protein protein] and ~~allowing targeted action~~. ~~Their~~ main role is ~~to cleave~~ ubiquitin ~~bound to a substrate~~, ~~often~~ a protein. ~~Ubiquitin, bound to~~ the ~~substrate, allows it~~ to regulate ~~its~~ degradation by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], ~~influences~~ its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>

'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes are known to be encoded by the humans genome, making it a very large [https://en.wikipedia.org/wiki/Protein protein] family. This diversity allows targeted actions and a certains specificity. DUBs's main role is about cleaving specially ubiquitin-linked molecules, which are most of the time a protein. The fate of an ubiquitin-tagged protein depends in part of the length of the ubiquitin chain(s) and on the configuration of ubiquitin-ubiquitin linkages in the chain considered. The tag is going in particular to regulate the degradation of the tagged-molecule by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], influence its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>

== Generalities ==

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 ==Deubiquitinases==
 <StructureSection load='3TMP' size='340' side='right' caption='The catalytic domain of human deubiquitinase DUBA in complex with ubiquitin aldehyde' scene=''>
-'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes exist in humans, making it a very diverse [https://en.wikipedia.org/wiki/Protein protein] and allowing targeted action. Their main role is to cleave ubiquitin bound to a substrate, often a protein. Ubiquitin, bound to the substrate, allows it to regulate its degradation by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], influences its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>
+'''Deubiquitinating enzymes or Deubiquitinases (DUBs)''' are [https://en.wikipedia.org/wiki/Enzyme enzymes] with an ubiquitin-dependent action. More than a hundred DUBs genes are known to be encoded by the humans genome, making it a very large [https://en.wikipedia.org/wiki/Protein protein] family. This diversity allows targeted actions and a certains specificity. DUBs's main role is about cleaving specially ubiquitin-linked molecules, which are most of the time a protein. The fate of an ubiquitin-tagged protein depends in part of the length of the ubiquitin chain(s) and on the configuration of ubiquitin-ubiquitin linkages in the chain considered. The tag is going in particular to regulate the degradation of the tagged-molecule by the [https://en.wikipedia.org/wiki/Proteasome proteasome] or [https://en.wikipedia.org/wiki/Lysozyme lysozyme], influence its cellular localisation or modulates the activity with another protein. <ref>PMID:17218518</ref><ref>PMID:12860974</ref>
 == Generalities ==