Sandbox Reserved 1656: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 65: | Line 65: | ||
The enzyme Otubain 1 is a deubiquitinase belonging to the Otubain family of proteases. The role of OTUB1 is not yet clearly defined, some studies show the correlation between tumor growth and OTUB1 while others show no involvement or suppression of the tumor by this enzyme. This suggests that the effects of OTUB1 depend on the stage and the tumor itself. However, the therapeutic targeting of OTUB1 could be used for patients with various tumors, since the enzyme is found in many tissues and has a high level of cell expression. <ref>PMID:30400005</ref> | The enzyme Otubain 1 is a deubiquitinase belonging to the Otubain family of proteases. The role of OTUB1 is not yet clearly defined, some studies show the correlation between tumor growth and OTUB1 while others show no involvement or suppression of the tumor by this enzyme. This suggests that the effects of OTUB1 depend on the stage and the tumor itself. However, the therapeutic targeting of OTUB1 could be used for patients with various tumors, since the enzyme is found in many tissues and has a high level of cell expression. <ref>PMID:30400005</ref> | ||
</StructureSection> | </StructureSection> | ||
==== Treatment ==== | ==== Treatment ==== | ||
DUBs are attractive targets for drug therapy. As a result, they may be used for it because they are widely involved in key regulatory processes. In fact, DUBs might function to regulate both stability and the activity of target proteins like oncogenes and tumor suppressors. (ref 16 a joutée) | DUBs are attractive targets for drug therapy. As a result, they may be used for it because they are widely involved in key regulatory processes. In fact, DUBs might function to regulate both stability and the activity of target proteins like oncogenes and tumor suppressors. (ref 16 a joutée) | ||
== References == | |||
<references/> | |||
