Sandbox Reserved 1647: Difference between revisions
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==Location== | ==Location== | ||
TBX21 protein is coded by the [https://en.wikipedia.org/wiki/TBX21 TBX21] gene on the chromosome 17 in humans. More precisely on the band 17q21.32 | TBX21 protein is coded by the [https://en.wikipedia.org/wiki/TBX21 TBX21] gene on the chromosome 17 in humans. More precisely on the band 17q21.32 <ref name="TBX21 Gene - GeneCards">TBX21-GeneCards : TBX21 - T-box Transcription factor 21 :https://www.genecards.org/cgi-bin/carddisp.pl?gene=TBX21</ref>. | ||
== Structure and structural interactions == | == Structure and structural interactions == | ||
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== Biological roles of TBX21 == | == Biological roles of TBX21 == | ||
=== Regulation of Th cells differentiation by TBX21 === | === Regulation of Th cells differentiation by TBX21 === | ||
The transcription factor T-bet directs Th1 cell differentiation. The molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood but several hypotheses have already been made on the action's mechanism of T-bet | The transcription factor T-bet directs Th1 cell differentiation. The molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood but several hypotheses have already been made on the action's mechanism of T-bet <ref name="NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression">DOI 10.4049/jimmunol.1203403</ref>. | ||
We know that T-bet initiates Th1 lineage development from naive Thp cells by activating Th1 genetics and repressing the opposing Th2 programs. Th1 cells stimulate cellular immune response while Th2 stimulates humoral immune response and induces antibody production <ref name="The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection">DOI 10.3389/fimmu.2019.00606</ref>. | We know that T-bet initiates Th1 lineage development from naive Thp cells by activating Th1 genetics and repressing the opposing Th2 programs. Th1 cells stimulate cellular immune response while Th2 stimulates humoral immune response and induces antibody production <ref name="The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection">DOI 10.3389/fimmu.2019.00606</ref>. | ||
