Sandbox Reserved 1659: Difference between revisions
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<StructureSection load='2xl4' size='340' side='right' caption='Structure of LntA' scene=''> | <StructureSection load='2xl4' size='340' side='right' caption='Structure of LntA' scene=''> | ||
== '''LntA (Listeria nuclear targeted protein A): a virulence factor''' == | |||
== '''LntA (Listeria nuclear targeted protein A) : a virulence factor''' == | |||
Listeria monocytogenes is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sproyts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf] | Listeria monocytogenes is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sproyts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf] | ||
