Sandbox Reserved 1659: Difference between revisions

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== '''LntA : a virulence factor''' ==

Listeria monocytogenes [[Media: listeria monocytogenes.jpg]]is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sprouts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]

Listeria monocytogenes [[Media: listeria monocytogenes.jpg| thumb |left|360px| upright=10|'''NR2A submit structure''']] is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sprouts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]

While interferons (IFNs) are able to limit viral infections, their role in bacterial infection remains unclear. In the case of Listeria, the expression of interferons-stimulated-genes (ISG) enhances its pathogenicity. Lebreton et a.l solved the 3D structure of LntA by x-rays crystallography (PDBID: 2XL4) in order to elucidate the molecular mechanisms of the host's transcriptional machinery[https://journals.asm.org/doi/full/10.1128/mBio.00775-13].

Sandbox Reserved 1659: Difference between revisions

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 == '''LntA : a virulence factor''' ==
-Listeria monocytogenes [[Media: listeria monocytogenes.jpg]]is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sprouts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]
+Listeria monocytogenes [[Media: listeria monocytogenes.jpg| thumb |left|360px| upright=10|'''NR2A submit structure''']] is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis [https://www.nhs.uk/conditions/meningitis/].The infection is caused by eating contaminated food such as raw sprouts, raw milk, smoked fish or soft cheese. It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]
 While interferons (IFNs) are able to limit viral infections, their role in bacterial infection remains unclear. In the case of Listeria, the expression of interferons-stimulated-genes (ISG) enhances its pathogenicity. Lebreton et a.l solved the 3D structure of LntA by x-rays crystallography (PDBID: 2XL4) in order to elucidate the molecular mechanisms of the host's transcriptional machinery[https://journals.asm.org/doi/full/10.1128/mBio.00775-13].