Sandbox Reserved 1660: Difference between revisions
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The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>. | The stability of the CD1d-glycolipid complexes has an impact on the [https://en.wikipedia.org/wiki/Cytokine cytokine] release (cell signaling). Conformational variations that would stabilize the F’-pocket (primary site of interaction with the T cell receptor, NKT TCR) might increase CD1d affinity for the NKT TCR<ref name="affinity"/><ref name="site"/>. | ||
</p> | </p> | ||
The <scene name='86/868193/Conformational_variations/1'>conformational variations</scene> | |||
The binding of a ligand (such as C12-di-sulfatide) leads to <scene name='86/868193/Conformational_variations/1'>conformational variations</scene> of CD1d molecule (The moving molecules are the oligosaccharides molecules ; the ligand is not represented). | |||
==== CD1d affinity ==== | ==== CD1d affinity ==== | ||
