Sandbox Reserved 1660: Difference between revisions

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The orientation of the immune pathway (Th1 or Th2) due to the cytokines secretion by NKT cells is dependant of the affinity of the ligand for ~~CD1~~ molecule. The design of agonists with a higher or lower affinity for ~~CD1~~ could also lead to therapeutic effects, due to the possibility of specifically directing the immune response towards the Th1 or Th2 pathway <ref name="site"/> <ref> Kishi J, Inuki S, Hirata N, Kashiwabara E, Yoshidome D, Ichihara O, Fujimoto Y. Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators. Bioorg Med Chem Lett. 2019 Apr 15;29(8):970-973. http://doi.org/10.1016/j.bmcl.2019.02.018. Epub 2019 Feb 18. PMID: 30824201.</ref>.

The orientation of the immune pathway (Th1 or Th2) due to the cytokines secretion by NKT cells is dependant of the affinity of the ligand for CD1d molecule. The design of agonists with a higher or lower affinity for CD1d could also lead to therapeutic effects, due to the possibility of specifically directing the immune response towards the Th1 or Th2 pathway <ref name="site"/> <ref> Kishi J, Inuki S, Hirata N, Kashiwabara E, Yoshidome D, Ichihara O, Fujimoto Y. Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators. Bioorg Med Chem Lett. 2019 Apr 15;29(8):970-973. http://doi.org/10.1016/j.bmcl.2019.02.018. Epub 2019 Feb 18. PMID: 30824201.</ref>.

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Sandbox Reserved 1660: Difference between revisions

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-The orientation of the immune pathway (Th1 or Th2) due to the cytokines secretion by NKT cells is dependant of the affinity of the ligand for CD1 molecule. The design of agonists with a higher or lower affinity for CD1 could also lead to therapeutic effects, due to the possibility of specifically directing the immune response towards the Th1 or Th2 pathway <ref name="site"/> <ref> Kishi J, Inuki S, Hirata N, Kashiwabara E, Yoshidome D, Ichihara O, Fujimoto Y. Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators. Bioorg Med Chem Lett. 2019 Apr 15;29(8):970-973. http://doi.org/10.1016/j.bmcl.2019.02.018. Epub 2019 Feb 18. PMID: 30824201.</ref>.
+The orientation of the immune pathway (Th1 or Th2) due to the cytokines secretion by NKT cells is dependant of the affinity of the ligand for CD1d molecule. The design of agonists with a higher or lower affinity for CD1d could also lead to therapeutic effects, due to the possibility of specifically directing the immune response towards the Th1 or Th2 pathway <ref name="site"/> <ref> Kishi J, Inuki S, Hirata N, Kashiwabara E, Yoshidome D, Ichihara O, Fujimoto Y. Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators. Bioorg Med Chem Lett. 2019 Apr 15;29(8):970-973. http://doi.org/10.1016/j.bmcl.2019.02.018. Epub 2019 Feb 18. PMID: 30824201.</ref>.
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