Sandbox Reserved 1660: Difference between revisions

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'''[[CD1]] (Cluster of Differentiation 1)''' is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to [https://en.wikipedia.org/wiki/Natural_killer_T_cell NKT cells]. ~~Among these~~ CD1~~-presenting cells can be counted~~ splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes. The CD1 family is made of three groups. Group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins. The third group is the CD1e, which shares some partial characteristics from groups 1 and 2<ref>Jullien, D.; Afanassieff, M.; Claudy, A.; Nicolas, J.; Kaiserlian, D. CD1 : une nouvelle famille de molécules présentatrices d’antigènes aux caractéristiques singulières. Med Sci (Paris) 1999, 15 (1), 7. https://doi.org/10.4267/10608/1190.</ref> <ref>Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem. 2000 Dec 1;275(48):37757-64. http://doi.org/10.1074/jbc.M007082200/</ref>.

'''[[CD1]] (Cluster of Differentiation 1)''' is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to [https://en.wikipedia.org/wiki/Natural_killer_T_cell NKT cells]. CD1 molecules are notably expressed by splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes. The CD1 family is made of three groups. Group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins. The third group is the CD1e, which shares some partial characteristics from groups 1 and 2<ref>Jullien, D.; Afanassieff, M.; Claudy, A.; Nicolas, J.; Kaiserlian, D. CD1 : une nouvelle famille de molécules présentatrices d’antigènes aux caractéristiques singulières. Med Sci (Paris) 1999, 15 (1), 7. https://doi.org/10.4267/10608/1190.</ref> <ref>Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem. 2000 Dec 1;275(48):37757-64. http://doi.org/10.1074/jbc.M007082200/</ref>.

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Thus, the structure and function of such proteins in mice are akin to those of humans. Mice do not express group 1 CD1 molecules, but they have two kinds of CD1d molecules. Therefore, mice have been widely used to characterize the functions of CD1d and CD1d-dependent NKT cells in many diseases.

Sandbox Reserved 1660: Difference between revisions

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-'''[[CD1]] (Cluster of Differentiation 1)''' is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to [https://en.wikipedia.org/wiki/Natural_killer_T_cell NKT cells]. Among these CD1-presenting cells can be counted splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes. The CD1 family is made of three groups. Group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins. The third group is the CD1e, which shares some partial characteristics from groups 1 and 2<ref>Jullien, D.; Afanassieff, M.; Claudy, A.; Nicolas, J.; Kaiserlian, D. CD1 : une nouvelle famille de molécules présentatrices d’antigènes aux caractéristiques singulières. Med Sci (Paris) 1999, 15 (1), 7. https://doi.org/10.4267/10608/1190.</ref> <ref>Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem. 2000 Dec 1;275(48):37757-64. http://doi.org/10.1074/jbc.M007082200/</ref>.
+'''[[CD1]] (Cluster of Differentiation 1)''' is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to [https://en.wikipedia.org/wiki/Natural_killer_T_cell NKT cells]. CD1 molecules are notably expressed by splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes. The CD1 family is made of three groups. Group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins. The third group is the CD1e, which shares some partial characteristics from groups 1 and 2<ref>Jullien, D.; Afanassieff, M.; Claudy, A.; Nicolas, J.; Kaiserlian, D. CD1 : une nouvelle famille de molécules présentatrices d’antigènes aux caractéristiques singulières. Med Sci (Paris) 1999, 15 (1), 7. https://doi.org/10.4267/10608/1190.</ref> <ref>Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H. Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J Biol Chem. 2000 Dec 1;275(48):37757-64. http://doi.org/10.1074/jbc.M007082200/</ref>.
 <br>
 Thus, the structure and function of such proteins in mice are akin to those of humans. Mice do not express group 1 CD1 molecules, but they have two kinds of CD1d molecules. Therefore, mice have been widely used to characterize the functions of CD1d and CD1d-dependent NKT cells in many diseases.