2ixo: Difference between revisions

<table><tr><td colspan='2'>[[2ixo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IXO FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ixp|2ixp]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ixo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixo OCA], [http://pdbe.org/2ixo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ixo RCSB], [http://www.ebi.ac.uk/pdbsum/2ixo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixo ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PTPA1_YEAST PTPA1_YEAST]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. Involved in the regulation of cell cycle progression, mitotic spindle formation, bud morphogenesis and DNA repair.<ref>PMID:11262194</ref> <ref>PMID:11134337</ref> <ref>PMID:12952889</ref> <ref>PMID:15150670</ref> <ref>PMID:15689491</ref> <ref>PMID:16380387</ref>