2j8j: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2j8j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8J OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2J8J FirstGlance].

<table><tr><td colspan='2'>[[2j8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2J8J FirstGlance].

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[https://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=2j8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8j OCA], [~~http~~://pdbe.org/2j8j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2j8j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2j8j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8j ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2j8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8j OCA], [https://pdbe.org/2j8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8j RCSB], [https://www.ebi.ac.uk/pdbsum/2j8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8j ProSAT]</td></tr>

</table>

== Disease ==

[[~~http~~://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[~~http~~://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>

[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='2j8j' size='340' side='right'caption='[[2j8j]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2j8j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2J8J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2j8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J8J FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xx9|1xx9]], [[1xxd|1xxd]], [[1xxf|1xxf]], [[1zhm|1zhm]], [[1zhp|1zhp]], [[1zhr|1zhr]], [[1zjd|1zjd]], [[1zlr|1zlr]], [[1zmj|1zmj]], [[1zml|1zml]], [[1zmn|1zmn]], [[1zom|1zom]], [[1zpz|1zpz]], [[1zrk|1zrk]], [[1zsj|1zsj]], [[1zsk|1zsk]], [[1zsl|1zsl]], [[1ztj|1ztj]], [[1ztk|1ztk]], [[1ztl|1ztl]], [[2j8l|2j8l]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xx9|1xx9]], [[1xxd|1xxd]], [[1xxf|1xxf]], [[1zhm|1zhm]], [[1zhp|1zhp]], [[1zhr|1zhr]], [[1zjd|1zjd]], [[1zlr|1zlr]], [[1zmj|1zmj]], [[1zml|1zml]], [[1zmn|1zmn]], [[1zom|1zom]], [[1zpz|1zpz]], [[1zrk|1zrk]], [[1zsj|1zsj]], [[1zsk|1zsk]], [[1zsl|1zsl]], [[1ztj|1ztj]], [[1ztk|1ztk]], [[1ztl|1ztl]], [[2j8l|2j8l]]</div></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2j8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8j OCA], [http://pdbe.org/2j8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j8j RCSB], [http://www.ebi.ac.uk/pdbsum/2j8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8j ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j8j OCA], [https://pdbe.org/2j8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j8j RCSB], [https://www.ebi.ac.uk/pdbsum/2j8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j8j ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[http://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
+[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
+[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]