Sandbox Reserved 1656: Difference between revisions
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== Biological role == | == Biological role == | ||
DUBs are involved at multiple levels in the [[ubiquitin]] pathway. The modifications made by DUBs are post-translational modifications. Depending on the level, DUBs have different functions. Two specific cellular functions exist for deubiquitinases. They may act either on the degradation of the stabilization of a substrate in particular <ref>DOI:https://doi.org/10.1080/10409239891204251</ref>. Further functions are more specifically related to the ubiquitin molecule. Here are some of them : | DUBs are involved at multiple levels in the [[ubiquitin]] pathway. The modifications made by DUBs are post-translational modifications. Depending on the level, DUBs have different functions. Two specific cellular functions exist for deubiquitinases. They may act either on the degradation of the stabilization of a substrate in particular <ref>Alan D’Andrea, David Pellman,Deubiquitinating Enzymes: A New Class of Biological Regulators, Taylor and Francis Online, Sept 29 2008,DOI: https://doi.org/10.1080/10409239891204251</ref>. Further functions are more specifically related to the ubiquitin molecule. Here are some of them : | ||
A : '''maturation of ubiquitin'''. When ubiquitin molecules are synthesized, they are not in free form. Thus, DUBs are essential for the generation of free monomers from precursors. The degradation of precursors is carried out by several DUBs belonging to the USPs class. | A : '''maturation of ubiquitin'''. When ubiquitin molecules are synthesized, they are not in free form. Thus, DUBs are essential for the generation of free monomers from precursors. The degradation of precursors is carried out by several DUBs belonging to the USPs class. | ||
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[[Image:DUBspathways.PNG |thumb|center|Figure 1 : Role of DUBs in the ubiquitin pathways]] | [[Image:DUBspathways.PNG |thumb|center|Figure 1 : Role of DUBs in the ubiquitin pathways]] | ||
Some other deubiquitinating enzymes also have biological functions. The latter are for instance involved in growth control, transcription silencing, regulation and viral infection or even the processing of ubiquitin-like-modifications.<ref>DOI:https://doi.org/10.1080/10409239891204251</ref> | Some other deubiquitinating enzymes also have biological functions. The latter are for instance involved in growth control, transcription silencing, regulation and viral infection or even the processing of ubiquitin-like-modifications.<ref>Alan D’Andrea, David Pellman,Deubiquitinating Enzymes: A New Class of Biological Regulators, Taylor and Francis Online, Sept 29 2008,DOI: https://doi.org/10.1080/10409239891204251</ref> | ||
== Disease == | == Disease == | ||
