Sandbox Reserved 1659: Difference between revisions

In addition, Lebreton et al showed that when listeria grows outside the cell, the transcription rate of LntA is almost null and that a constitutive expression of LntA has an antibacterial effect. Thus, the efficiency of LntA requires a precise temporal and quantitative regulation.

The discovery of the LntA virulence factor shows that pathogenic bacteria can implement complex infectious strategies, requiring very precise temporal and quantitative regulation of the virulence factor delivery. Studies on virulence factors that target the nucleus can lead to the discovery of new mechanisms of gene expression regulation. And more importantly, the understanding these dialogs might allow new drug design and possibly a better support of the patients. Furthermore, the awareness of such mechanisms is very recent and raises many questions. For instance, it is still unclear whether the impact of lntA on gene expression is merely temporary or whether it leaves epigenetic marks over the long term.