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Listeria monocytogenes ~~[[Image: listeria monocytogenes.jpg#filehistory| thumb |left|360px| upright=10|'''listeria monocytogenes structure''']]~~ is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]

Listeria monocytogenes is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]

While interferons (IFNs) are able to limit viral infections, their role in bacterial infection remains unclear. In the case of Listeria, the expression of interferons-stimulated-genes (ISG) enhances its pathogenicity. Lebreton et a.l solved the 3D structure of LntA by x-rays crystallography (PDBID: 2XL4) in order to elucidate the molecular mechanisms of the host's transcriptional machinery[https://journals.asm.org/doi/full/10.1128/mBio.00775-13].

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 <StructureSection load='2xl4' size='340' side='right' caption='Caption for this structure ' scene=''>
-Listeria monocytogenes [[Image: listeria monocytogenes.jpg#filehistory| thumb |left|360px| upright=10|'''listeria monocytogenes structure''']] is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis  It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]
+Listeria monocytogenes is an ubiquitous Gram + bacteria and is the only kind of Listeria which is pathogenic for humans. In fact, it is responsible for the human listeriosis which can range from gastroenteritis to fatal meningitis  It It is a rare but severe illness for pregnant women, elderly and immuno-compromised subjects with a death rate around 30%. During infection, the bacterium penetrates the cell and secretes multiple virulence factors that modulate the host's gene expression. LntA is one of these virulence factors and it targets Interferons-stimulated genes.[https://www.anses.fr/fr/system/files/BIORISK2016SA0081Fi.pdf]
 While interferons (IFNs) are able to limit viral infections, their role in bacterial infection remains unclear. In the case of Listeria, the expression of interferons-stimulated-genes (ISG) enhances its pathogenicity. Lebreton et a.l solved the 3D structure of LntA by x-rays crystallography (PDBID: 2XL4) in order to elucidate the molecular mechanisms of the host's transcriptional machinery[https://journals.asm.org/doi/full/10.1128/mBio.00775-13].