Sandbox Reserved 1657: Difference between revisions

'''[https://en.wikipedia.org/wiki/Notch_proteins NOTCH family] :''' The NOTCH family encodes [https://en.wikipedia.org/wiki/Cell_surface_receptor transmembrane receptor proteins] that are involved in cell fate determination during development. In the drosophila <ref name=Drosophila >DOI:10.1126/science.aab0988</ref> adult midgut, intestinal [https://en.wikipedia.org/wiki/Stem_cell stem cells] (ISCs) produce two types of daughter cells, the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837124/#:~:text=Enterocytes%20are%20specialized%20to%20absorb,along%20the%20crypt%2Dvillus%20axis. nutrient-absorbing enterocytes (ECs)] and [https://en.wikipedia.org/wiki/Enteroendocrine_cell secretory enteroendocrine cells]. Notch signalling between intestinal stem cells and their daughter cells guides cell specification. ISCs with elevated levels of the Notch Delta ligand more primarily activate the Notch signalling pathway in daughter cells and cause them to become ECs. However, ISCs having low levels of Notch Delta ligand direct daughter cells to become enteroendocrine cells.