Sandbox Reserved 1649: Difference between revisions
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NR2A is a protein which is a part of [https://en.wikipedia.org/wiki/NMDA_receptor NMDA receptors], that are heterodimer channels composed of four subunits. Indeed, NMDA receptors are made of the association between two NR2 and two NR1 proteins. NMDA receptors play a key role in mammalian central nervous system, as they act in Ca2+ influx in synapses in response to glutamate and glycine binding. Their role is essential for learning and memory. Variety of NR2 allows modulation of NMDAr. In the other hand, [https://www.youtube.com/watch?fbclid=IwAR163EHEh3RM8BXt-_4aiecrCgkF83HoyOefyU63d_CQwoqN5RHShYfLDnM&v=4-DuvwoH2zQ&feat NMDA receptors are related to AMPA receptors in the same synapse.] | NR2A is a protein which is a part of [https://en.wikipedia.org/wiki/NMDA_receptor NMDA receptors], that are heterodimer channels composed of four subunits. Indeed, NMDA receptors are made of the association between two NR2 and two NR1 proteins. NMDA receptors play a key role in mammalian central nervous system, as they act in Ca2+ influx in synapses in response to glutamate and glycine binding. Their role is essential for learning and memory. Variety of NR2 allows modulation of NMDAr. In the other hand, [https://www.youtube.com/watch?fbclid=IwAR163EHEh3RM8BXt-_4aiecrCgkF83HoyOefyU63d_CQwoqN5RHShYfLDnM&v=4-DuvwoH2zQ&feat NMDA receptors are related to AMPA receptors in the same synapse.] | ||
[[Image:Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1.png]] | |||
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== NR1/NR2A complex == | == NR1/NR2A complex [[https://youtu.be/BHuQ8qhHF60]] == | ||
NR2A can be found in some NMDA receptors, in which NR2A is associated to NR1. NMDA receptors are necessarily heteromers of 4 subunits, organized as a dimer of dimers. These dimers are heterodimers constituted with a glycine binding NR1 and a glutamate binding subunits NR2. | NR2A can be found in some NMDA receptors, in which NR2A is associated to NR1. NMDA receptors are necessarily heteromers of 4 subunits, organized as a dimer of dimers. These dimers are heterodimers constituted with a glycine binding NR1 and a glutamate binding subunits NR2. | ||
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Since the opening of the NMDA channel requires both glutamate and glycine, respectively detected by NR2 and NR1, the association between NR1 and NR2A is primordial. | Since the opening of the NMDA channel requires both glutamate and glycine, respectively detected by NR2 and NR1, the association between NR1 and NR2A is primordial. | ||
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[[Image:NR1 NR2A.png | thumb ]] | |||
