Sandbox Reserved 1659: Difference between revisions
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The discovery of the LntA virulence factor shows that pathogenic bacteria can implement complex infectious strategies, requiring very precise temporal and quantitative regulation of the virulence factor delivery. Studies on virulence factors that target the nucleus can lead to the discovery of new mechanisms of gene expression regulation. And more importantly, the understanding these dialogs might allow new drug design and possibly a better support of the patients. Furthermore, the awareness of such mechanisms is very recent and raises many questions. For instance, it is still unclear whether the impact of lntA on gene expression is merely temporary or whether it leaves epigenetic marks over the long term. | The discovery of the LntA virulence factor shows that pathogenic bacteria can implement complex infectious strategies, requiring very precise temporal and quantitative regulation of the virulence factor delivery. Studies on virulence factors that target the nucleus can lead to the discovery of new mechanisms of gene expression regulation. And more importantly, the understanding these dialogs might allow new drug design and possibly a better support of the patients. Furthermore, the awareness of such mechanisms is very recent and raises many questions. For instance, it is still unclear whether the impact of lntA on gene expression is merely temporary or whether it leaves epigenetic marks over the long term. | ||
Key points about LntA: - Is a virulence factor of L. monocytogenes | Key points about LntA: '''Function:''' | ||
- Is a virulence factor of L. monocytogenes | |||
- Interacts with BAHD1, a transcription factor, in the nucleus | - Interacts with BAHD1, a transcription factor, in the nucleus | ||
- Remove the chromatin repressors from the host's DNA | - Remove the chromatin repressors from the host's DNA | ||
- Triggers the formation of interferons | - Triggers the formation of interferons | ||
'''Structure:''' | |||
-A 9.7 kDa protein | |||
-Made up of five alpha-helixes | |||
-H4 and H5 responsible of the interaction with BAHD1 | |||
