Sandbox Reserved 1099: Difference between revisions

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However, some cleavages of the precursor occur probably in sweat to produce different active forms of dermcidin peptide. The most abundant proteolytically processed DCD peptide present in sweat is '''DCD-1L''' (amino acid sequence in bold).

DCD-1L is created by proteases in sweat. The first post-secretory processing step consists in reducing the C-terminal of the peptide containing 48 residues, from 63 to 110 amino acids. Then, the [https://www.uniprot.org/uniprot/P07339_ cathepsin D]an protease, with 1,10-phenthroline-sensitive and another unidentified endoprotease contribute to further processed the DCD-1L C-terminal to produce other derived-peptides (12 have been discovered)<ref name="baechle">Daniel Baechle, Thomas Flad, Alexander Cansier, Heiko Steffen, Birgit Schittek, Jonathan Tolson, Timo Herrmann, Hassan Dihazi􏰀, Alexander Beck, Gerhard A. Mueller􏰀, Margret Mueller, Stefan Stevanovic, Claus Garbe, Claudia A. Mueller, and Hubert Kalbacher. "Cathepsin D Is Present in Human Eccrine Sweat and Involved in the Postsecretory Processing of the Antimicrobial Peptide DCD-1L" J. Biol. Chem. 281, no. 9 (March 3, 2006): 5406-15. https://doi.org/10.1074/jbc.M504670200 </ref>. One of them is DCD-1 which lacks the last leucine.

DCD-1L is created by proteases in sweat. The first post-secretory processing step consists in reducing the C-terminal of the peptide containing 48 residues, from 63 to 110 amino acids. Then, the [https://www.uniprot.org/uniprot/P07339_ cathepsin D], an protease, with 1,10-phenthroline-sensitive and another unidentified endoprotease contribute to further processed the DCD-1L C-terminal to produce other derived-peptides (12 have been discovered)<ref name="baechle">Daniel Baechle, Thomas Flad, Alexander Cansier, Heiko Steffen, Birgit Schittek, Jonathan Tolson, Timo Herrmann, Hassan Dihazi􏰀, Alexander Beck, Gerhard A. Mueller􏰀, Margret Mueller, Stefan Stevanovic, Claus Garbe, Claudia A. Mueller, and Hubert Kalbacher. "Cathepsin D Is Present in Human Eccrine Sweat and Involved in the Postsecretory Processing of the Antimicrobial Peptide DCD-1L" J. Biol. Chem. 281, no. 9 (March 3, 2006): 5406-15. https://doi.org/10.1074/jbc.M504670200 </ref>. One of them is DCD-1 which lacks the last leucine.

== Structural highlights ==

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 However, some cleavages of the precursor occur probably in sweat to produce different active forms of dermcidin peptide. The most abundant proteolytically processed DCD peptide present in sweat is '''DCD-1L''' (amino acid sequence in bold).
-DCD-1L is created by proteases in sweat. The first post-secretory processing step consists in reducing the C-terminal of the peptide containing 48 residues, from 63 to 110 amino acids. Then, the [https://www.uniprot.org/uniprot/P07339_ cathepsin D]an protease, with 1,10-phenthroline-sensitive and another unidentified endoprotease contribute to further processed the DCD-1L C-terminal to produce other derived-peptides (12 have been discovered)<ref name="baechle">Daniel Baechle, Thomas Flad, Alexander Cansier, Heiko Steffen, Birgit Schittek, Jonathan Tolson, Timo Herrmann, Hassan Dihazi􏰀, Alexander Beck, Gerhard A. Mueller􏰀, Margret Mueller, Stefan Stevanovic, Claus Garbe, Claudia A. Mueller, and Hubert Kalbacher. "Cathepsin D Is Present in Human Eccrine Sweat and Involved in the Postsecretory Processing of the Antimicrobial Peptide DCD-1L" J. Biol. Chem. 281, no. 9 (March 3, 2006): 5406-15. https://doi.org/10.1074/jbc.M504670200 </ref>. One of them is DCD-1 which lacks the last leucine.
+DCD-1L is created by proteases in sweat. The first post-secretory processing step consists in reducing the C-terminal of the peptide containing 48 residues, from 63 to 110 amino acids. Then, the [https://www.uniprot.org/uniprot/P07339_ cathepsin D], an protease, with 1,10-phenthroline-sensitive and another unidentified endoprotease contribute to further processed the DCD-1L C-terminal to produce other derived-peptides (12 have been discovered)<ref name="baechle">Daniel Baechle, Thomas Flad, Alexander Cansier, Heiko Steffen, Birgit Schittek, Jonathan Tolson, Timo Herrmann, Hassan Dihazi􏰀, Alexander Beck, Gerhard A. Mueller􏰀, Margret Mueller, Stefan Stevanovic, Claus Garbe, Claudia A. Mueller, and Hubert Kalbacher. "Cathepsin D Is Present in Human Eccrine Sweat and Involved in the Postsecretory Processing of the Antimicrobial Peptide DCD-1L" J. Biol. Chem. 281, no. 9 (March 3, 2006): 5406-15. https://doi.org/10.1074/jbc.M504670200 </ref>. One of them is DCD-1 which lacks the last leucine.
 == Structural highlights ==