Sandbox Reserved 1099: Difference between revisions
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For instance, in he gastric cancer, cells are characterized by an overexpression of long non coding RNAs ([https://en.wikipedia.org/wiki/Long_non-coding_RNA_ lncRNA]) of stomach cancer associated transcript 3 (shortened as STCAT3). These RNAs, under the RNA form, run some functions of gene regulation such as gene expressions, control of the cell cycle, ect… Dermcidin has been identified as the binding protein of lncRNA STCAT3. | For instance, in he gastric cancer, cells are characterized by an overexpression of long non coding RNAs ([https://en.wikipedia.org/wiki/Long_non-coding_RNA_ lncRNA]) of stomach cancer associated transcript 3 (shortened as STCAT3). These RNAs, under the RNA form, run some functions of gene regulation such as gene expressions, control of the cell cycle, ect… Dermcidin has been identified as the binding protein of lncRNA STCAT3. | ||
In breast cancer dermcidin bind to the protein sGRP78. | In breast cancer dermcidin bind to the protein sGRP78. | ||
But also, in some case the dermcidin expression has been shown to be stronger cancer cells. So in the cancer cells the DCD can be found more abundant than in non-cancer cells. | But also, in some case the dermcidin expression has been shown to be stronger cancer cells. So in the cancer cells the DCD can be found more abundant than in non-cancer cells. These discoveries could be used in cancer's research.<ref> Zhang, J., Ding, W., Kuai, X., Ji, Y., Zhu, Z., Mao, Z., Wang, Z., 2018. Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer. Oncol Rep. https://doi.org/10.3892/or.2018.6673 </ref> | ||
Often times, dermcidin is in the discussion to function as a general '''biomarker''' for the above mentioned diseases but also being a potential '''target for anticancer drugs''' such as [https://www.biotrend-usa.com/other-products-186/seriniquinone-22200-69-7-566000900.html_ seriniquinone].<ref name="trzoss"/> The anticancer effect could derive from direct interaction or from protein complexes linked via disulfide bonds to DCD, which was already shown for [http://proteopedia.org/wiki/index.php/Hsp70_ Hsp70]. In the survival-promoting peptide area of dermcidin, GNPCH is considered to be an ATP-dependent binding-site for Hsp70.<ref> Stocki, P., Wang, X.N., Morris, N.J., Dickinson, A.M., 2011. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. J. Biol. Chem. 286, 12803–12811. https://doi.org/10.1074/jbc.M110.179630 </ref> | Often times, dermcidin is in the discussion to function as a general '''biomarker''' for the above mentioned diseases but also being a potential '''target for anticancer drugs''' such as [https://www.biotrend-usa.com/other-products-186/seriniquinone-22200-69-7-566000900.html_ seriniquinone].<ref name="trzoss"/> The anticancer effect could derive from direct interaction or from protein complexes linked via disulfide bonds to DCD, which was already shown for [http://proteopedia.org/wiki/index.php/Hsp70_ Hsp70]. In the survival-promoting peptide area of dermcidin, GNPCH is considered to be an ATP-dependent binding-site for Hsp70.<ref> Stocki, P., Wang, X.N., Morris, N.J., Dickinson, A.M., 2011. HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope. J. Biol. Chem. 286, 12803–12811. https://doi.org/10.1074/jbc.M110.179630 </ref> | ||
