Sandbox Reserved 1654: Difference between revisions

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=== ''' Function in memory ''' ===

Long-term and short-term memories differ by the duration of their retention. Long-term memory formation needs transcription and translation of stored mRNAs. CPEB operate in the post synaptic domain of neurons. CPEB is stimulated by a neuronal stimulation, it “activates translation of CaMKII and similar mRNAs. It also associates with motor proteins for mRNA transport and has a role in packaging of bound mRNAs to RNP complexes. CPEB initiates polyadenylation induced translation of dormant mRNAs during Xenopus oocyte maturation. In developing oocytes, following nuclear export, CPE containing mRNAs are bound by CPEB1 as well as other interacting proteins like PARN (poly A ribonuclease) and Gld2 (polyA polymerase), leading to removal of polyA tail of mRNAs, as PARN overrides Gld2 activity. This leads to translational suppression of mRNAs. However upon activity-induced phosphorylation of CPEB, PARN dissociates from the complex and the mRNA is polyadenylated leading to translation.”

[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449092/]

== ''' Diseases ''' ==

CPEB proteins play a key role in some diseases, especially in cancers. Indeed, in some humans tumors the level of CPEB 1 is lower than in healthy cells and this leads to the growth of these tumors. An overexpression of CPEB 4 can lead to tumor growth too. Some researches try to find a cancer treatment thanks to CPEB mutations<ref name="publi" />.

Sandbox Reserved 1654: Difference between revisions

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@@ Line 51: / Line 51: @@
 ===  ''' Function in memory ''' ===
+Long-term and short-term memories differ by the duration of their retention. Long-term memory formation needs transcription and translation of stored mRNAs. CPEB operate in the post synaptic domain of neurons. CPEB is stimulated by a neuronal stimulation, it “activates translation of CaMKII and similar mRNAs. It also associates with motor proteins for mRNA transport and has a role in packaging of bound mRNAs to RNP complexes. CPEB initiates polyadenylation induced translation of dormant mRNAs during Xenopus oocyte maturation. In developing oocytes, following nuclear export, CPE containing mRNAs are bound by CPEB1 as well as other interacting proteins like PARN (poly A ribonuclease) and Gld2 (polyA polymerase), leading to removal of polyA tail of mRNAs, as PARN overrides Gld2 activity. This leads to translational suppression of mRNAs. However upon activity-induced phosphorylation of CPEB, PARN dissociates from the complex and the mRNA is polyadenylated leading to translation.”
+[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449092/]
 == ''' Diseases ''' ==
 CPEB proteins play a key role in some diseases, especially in cancers. Indeed, in some humans tumors the level of CPEB 1 is lower than in healthy cells and this leads to the growth of these tumors. An overexpression of CPEB 4 can lead to tumor growth too. Some researches try to find a cancer treatment thanks to CPEB mutations<ref name="publi" />.