Sandbox Reserved 1648: Difference between revisions
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Leptin receptors are found in different regions depending on the short or long form of the protein. | Leptin receptors are found in different regions depending on the short or long form of the protein. | ||
The '''long form''' (Ob- | The '''long form''' (Ob-Rb) is mainly present in the [https://en.wikipedia.org/wiki/Hypothalamus '''hypothalamus'''], notably in the [https://en.wikipedia.org/wiki/Arcuate_nucleus arcuate nucleus], [https://en.wikipedia.org/wiki/Dorsomedial_hypothalamic_nucleus dorsomedial] and [https://en.wikipedia.org/wiki/Ventromedial_nucleus_of_the_hypothalamus ventromedial] nuclei, and in the paraventricular nucleus ([https://en.wikipedia.org/wiki/Paraventricular_nucleus_of_hypothalamus PVN]) <ref name="ref4"> Leptin : https://www.eurofins-biomnis.com/referentiel/liendoc/precis/LEPTINE.pdf </ref> <ref name="ref5"> La leptine : votre cerveau, l'appétit et l'obésité : https://www.societe-neuroendocrinologie.fr/Breves/03-La-leptine-votre-cerveau-l-appetit-et-l-obesite </ref> <ref name="ref6"> La leptine : une clé pour la reproduction : http://www.ipubli.inserm.fr/bitstream/handle/10608/1310/1999_2_191.pdf?sequence=2 </ref>. It is also found in lesser amounts in the [https://en.wikipedia.org/wiki/Pancreatic_islets '''islets of Langerhans'''] in mice, as well as in the '''liver''', '''spleen''', '''heart''', [https://en.wikipedia.org/wiki/White_adipose_tissue '''white fat'''], [https://en.wikipedia.org/wiki/Lymph_node '''lymph node'''], [https://en.wikipedia.org/wiki/Jejunum '''jejunum'''] and [https://en.wikipedia.org/wiki/Hematopoietic_stem_cell '''hematopoietic stem cells''']<ref name="ref2"/> <ref name="ref7"> Hormonal Regulation of Fuel Metabolism : https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/leptin-receptor </ref>. | ||
The '''short-form''' (Ob-Ra) is located primarily in the '''lungs''', '''kidneys''' and '''islets of Langerhans''' <ref name="ref4"/>. It is also present in smaller quantities in the brain at the '''hypothalamus'''.<ref name="ref5"/> Ob-Ra is the only form of the protein found in '''ovaries'''. Short form facilitates the passage of leptin across the blood cerebrospinal fluid barrier. | The '''short-form''' (Ob-Ra) is located primarily in the '''lungs''', '''kidneys''' and '''islets of Langerhans''' <ref name="ref4"/>. It is also present in smaller quantities in the brain at the '''hypothalamus'''.<ref name="ref5"/> Ob-Ra is the only form of the protein found in '''ovaries'''. Short form facilitates the passage of leptin across the blood cerebrospinal fluid barrier. | ||
