Sandbox Reserved 1098: Difference between revisions

Line 8:

== Catabolism of poly (ADP-ribose) ==

This protein has four principal domains on a <scene name='82/829351/Single_chain/1'>single peptide chain</scene>: an A-domain, a catalytic domain and two substrate binding domains~~[http://www.uniprot.org/uniprot/Q86W56]~~.

This protein has four principal domains on a <scene name='82/829351/Single_chain/1'>single peptide chain</scene>: an A-domain, a catalytic domain and two substrate binding domains.

The first 456 amino acids of the peptide chain form the <scene name='82/829351/A_domain/1'>A-domain</scene>. Then, from the 610th to the 795th amino acids the <scene name='82/829351/Catalytic_domain/1'>catalytic domain</scene> can be found. This catalytic domain can bind to other proteins with <scene name='82/829351/Substrat_-_catalytic_domain/1'>two amino acids</scene> (the 726th and 727th amino acids). Next, <scene name='82/829351/Subtrat_jonction_domain_2/1'>the second substrate binding domain</scene> is located from the 869th to the 874th amino acid. ~~[http://www.uniprot.org/uniprot/Q86W56]~~

The first 456 amino acids of the peptide chain form the <scene name='82/829351/A_domain/1'>A-domain</scene>. Then, from the 610th to the 795th amino acids the <scene name='82/829351/Catalytic_domain/1'>catalytic domain</scene> can be found. This catalytic domain can bind to other proteins with <scene name='82/829351/Substrat_-_catalytic_domain/1'>two amino acids</scene> (the 726th and 727th amino acids). Next, <scene name='82/829351/Subtrat_jonction_domain_2/1'>the second substrate binding domain</scene> is located from the 869th to the 874th amino acid.

As such, most of the amino acids form the A-domain and the catalytic domain and only a few amino acids (8 a.a) make links with other proteins. Moreover, the ligand 7JB can bind the protein on the <scene name='82/829351/Liason_7jb/1'>754, 758, 792 and 795 amino acids</scene>. These amino acids are located on a helix and on a beta sheet~~. [http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=6HMM]~~. There is the <scene name='82/829351/Distritbution_domain/1'>following</scene> amino acid distribution.

As such, most of the amino acids form the A-domain and the catalytic domain and only a few amino acids (8 a.a) make links with other proteins. Moreover, the ligand 7JB can bind the protein on the <scene name='82/829351/Liason_7jb/1'>754, 758, 792 and 795 amino acids</scene>. These amino acids are located on a helix and on a beta sheet. There is the <scene name='82/829351/Distritbution_domain/1'>following</scene> amino acid distribution [http://www.uniprot.org/uniprot/Q86W56].

The protein <scene name='82/829351/Parg/1'>PARG</scene> folds into an ADP-ribose-binding macro domain with an N-terminal extension. It also consists of a diphosphate-binding loop on one side of an ADP-ribose binding cavity. On the other side there are several amino acids matching to the specific <scene name='82/829351/Parg/1'>PARG</scene> signature sequence.

Sandbox Reserved 1098: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 8: / Line 8: @@
 == Catabolism of poly (ADP-ribose) ==
-This protein has four principal domains on a <scene name='82/829351/Single_chain/1'>single peptide chain</scene>: an A-domain, a catalytic domain and two substrate binding domains[http://www.uniprot.org/uniprot/Q86W56].
+This protein has four principal domains on a <scene name='82/829351/Single_chain/1'>single peptide chain</scene>: an A-domain, a catalytic domain and two substrate binding domains.
-The first 456 amino acids of the peptide chain form the <scene name='82/829351/A_domain/1'>A-domain</scene>. Then, from the 610th to the 795th amino acids the <scene name='82/829351/Catalytic_domain/1'>catalytic domain</scene> can be found. This catalytic domain can bind to other proteins with <scene name='82/829351/Substrat_-_catalytic_domain/1'>two amino acids</scene> (the 726th and 727th amino acids). Next, <scene name='82/829351/Subtrat_jonction_domain_2/1'>the second substrate binding domain</scene> is located from the 869th to the 874th amino acid. [http://www.uniprot.org/uniprot/Q86W56]
+The first 456 amino acids of the peptide chain form the <scene name='82/829351/A_domain/1'>A-domain</scene>. Then, from the 610th to the 795th amino acids the <scene name='82/829351/Catalytic_domain/1'>catalytic domain</scene> can be found. This catalytic domain can bind to other proteins with <scene name='82/829351/Substrat_-_catalytic_domain/1'>two amino acids</scene> (the 726th and 727th amino acids). Next, <scene name='82/829351/Subtrat_jonction_domain_2/1'>the second substrate binding domain</scene> is located from the 869th to the 874th amino acid.
-As such, most of the amino acids form the A-domain and the catalytic domain and only a few amino acids (8 a.a) make links with other proteins. Moreover, the ligand 7JB can bind the protein on the <scene name='82/829351/Liason_7jb/1'>754, 758, 792 and 795 amino acids</scene>. These amino acids are located on a helix and on a beta sheet. [http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=6HMM]. There is the <scene name='82/829351/Distritbution_domain/1'>following</scene> amino acid distribution.
+As such, most of the amino acids form the A-domain and the catalytic domain and only a few amino acids (8 a.a) make links with other proteins. Moreover, the ligand 7JB can bind the protein on the <scene name='82/829351/Liason_7jb/1'>754, 758, 792 and 795 amino acids</scene>. These amino acids are located on a helix and on a beta sheet. There is the <scene name='82/829351/Distritbution_domain/1'>following</scene> amino acid distribution [http://www.uniprot.org/uniprot/Q86W56].
 The protein <scene name='82/829351/Parg/1'>PARG</scene> folds into an ADP-ribose-binding macro domain with an N-terminal extension. It also consists of a diphosphate-binding loop on one side of an ADP-ribose binding cavity. On the other side there are several amino acids matching to the specific <scene name='82/829351/Parg/1'>PARG</scene> signature sequence.