Perforin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 5: | Line 5: | ||
'''Cytolysis/Apoptosis''' | '''Cytolysis/Apoptosis''' | ||
'''Perforin''' is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis. | '''Perforin''' is a glycoprotein that is responsible for the pore formation of target cells (T-cells) in the cell membranes. Perforin is stored in the lysosome-like secretory granules of cytotoxic T lymphocytes. This protein is utilized by natural killer (NK) cells and CD8-positive T-cells. Perforin can also be expressed in low amounts in CD4-positive T-cells whenever classic cytotoxicity is disrupted. NK cells and T-cells use perforin molecules to create channels that allow for the transport of ions, water, small-molecule substances, and enzymes. By forming these channels, perforin causes problems with the disruptive barrier of the membranes and thus destroys the solidarity of the T-cells. This is why their function can broadly be identified as apoptosis. | ||
See also [[Cytolysin]]. | |||
== Mechanism == | == Mechanism == | ||
