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| ==Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine== | | ==Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine== |
| <StructureSection load='3ckx' size='340' side='right' caption='[[3ckx]], [[Resolution|resolution]] 2.70Å' scene=''> | | <StructureSection load='3ckx' size='340' side='right'caption='[[3ckx]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[3ckx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CKX FirstGlance]. <br> | | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKX FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckx OCA], [https://pdbe.org/3ckx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckx RCSB], [https://www.ebi.ac.uk/pdbsum/3ckx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckx ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3ckx TOPSAN]</span></td></tr> |
| <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ckw|3ckw]]</td></tr>
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| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STK24, MST3, STK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckx OCA], [http://pdbe.org/3ckx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ckx RCSB], [http://www.ebi.ac.uk/pdbsum/3ckx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckx ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3ckx TOPSAN]</span></td></tr> | |
| </table> | | </table> |
| == Function ==
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| [[http://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN]] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>
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| == Evolutionary Conservation == | | == Evolutionary Conservation == |
| [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| ==See Also== | | ==See Also== |
| *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] |
| == References ==
| |
| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Human]] | | [[Category: Large Structures]] |
| [[Category: Non-specific serine/threonine protein kinase]]
| | [[Category: Antonysamy SS]] |
| [[Category: Antonysamy, S S]] | | [[Category: Buchanan S]] |
| [[Category: Buchanan, S]] | | [[Category: Burley SK]] |
| [[Category: Burley, S K]] | | [[Category: Chau F]] |
| [[Category: Chau, F]] | | [[Category: Feil I]] |
| [[Category: Feil, I]] | | [[Category: Sauder JM]] |
| [[Category: Structural genomic]]
| | [[Category: Wu L]] |
| [[Category: Sauder, J M]] | |
| [[Category: Wu, L]] | |
| [[Category: Alternative splicing]]
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| [[Category: Atp-binding]]
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| [[Category: Cytoplasm]]
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| [[Category: Mst3]]
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| [[Category: Nucleotide-binding]]
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| [[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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| [[Category: Phosphoprotein]]
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| [[Category: Protein kinase]]
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| [[Category: PSI, Protein structure initiative]]
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| [[Category: Serine/threonine-protein kinase]]
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| [[Category: Staurosporine]]
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| [[Category: Sterile 20-like kinase]]
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| [[Category: Stk24]]
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| [[Category: Transferase]]
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