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==Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail==
==Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail==
<StructureSection load='3ct1' size='340' side='right' caption='[[3ct1]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
<StructureSection load='3ct1' size='340' side='right'caption='[[3ct1]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ct1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_phi-29 Bacteriophage phi-29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CT1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ct1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_phi-29 Bacteriophage phi-29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CT1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3csq|3csq]], [[3csr|3csr]], [[3csz|3csz]], [[3ct0|3ct0]], [[3ct5|3ct5]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3csq|3csq]], [[3csr|3csr]], [[3csz|3csz]], [[3ct0|3ct0]], [[3ct5|3ct5]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 Bacteriophage phi-29])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">13 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 Bacteriophage phi-29])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ct1 OCA], [http://pdbe.org/3ct1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ct1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ct1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ct1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ct1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ct1 OCA], [https://pdbe.org/3ct1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ct1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ct1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ct1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VG13_BPPH2 VG13_BPPH2]] Essential for tail assembly and the production of infectious particles. Degrades the peptidoglycan layer of the host cell wall and thereby facilitates infection of host bacteria. Acts probably as multifunctional enzyme that degrades N-acetylglucosamine polymers (in vitro) and cleaves the peptide cross-links of the host cell wall (Probable).<ref>PMID:18394643</ref> <ref>PMID:18606992</ref>   
[[https://www.uniprot.org/uniprot/VG13_BPPH2 VG13_BPPH2]] Essential for tail assembly and the production of infectious particles. Degrades the peptidoglycan layer of the host cell wall and thereby facilitates infection of host bacteria. Acts probably as multifunctional enzyme that degrades N-acetylglucosamine polymers (in vitro) and cleaves the peptide cross-links of the host cell wall (Probable).<ref>PMID:18394643</ref> <ref>PMID:18606992</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ct1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ct/3ct1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Bacteriophage phi-29]]
[[Category: Bacteriophage phi-29]]
[[Category: Large Structures]]
[[Category: Rossmann, M G]]
[[Category: Rossmann, M G]]
[[Category: Xiang, Y]]
[[Category: Xiang, Y]]
Retrieved from "https://proteopedia.org/3ct1"