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==Methyltransferase domain of human PR domain-containing protein 1==
==Methyltransferase domain of human PR domain-containing protein 1==
<StructureSection load='3dal' size='340' side='right' caption='[[3dal]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='3dal' size='340' side='right'caption='[[3dal]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DAL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM1, BLIMP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM1, BLIMP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dal OCA], [http://pdbe.org/3dal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dal RCSB], [http://www.ebi.ac.uk/pdbsum/3dal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dal ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dal OCA], [https://pdbe.org/3dal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dal RCSB], [https://www.ebi.ac.uk/pdbsum/3dal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dal ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PRDM1_HUMAN PRDM1_HUMAN]] Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.  
[[https://www.uniprot.org/uniprot/PRDM1_HUMAN PRDM1_HUMAN]] Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dal_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/3dal_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Amaya, M F]]
[[Category: Amaya, M F]]
[[Category: Antoshenko, T]]
[[Category: Antoshenko, T]]

Revision as of 07:58, 2 February 2022

Methyltransferase domain of human PR domain-containing protein 1

3dal, resolution 1.65Å

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