Theoretical Model:
The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.
Model Confidence:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.
To the right is an AlphaFold2 3D model of SARS CoV-2 Protein (UniProt ID: QHD43419) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 4[1].
Function
Disease
Function
Protein M
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.[2][3]]
Disease
Relevance
Structural highlights
Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein M, rainbow color coded N-C[1].
↑Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:https://dx.doi.org/10.1021/acs.jproteome.0c00129