Pteridine reductase

spinqualitylabelsall models Structure of pteridine reductase complex with NADPH, tetrahydrobiopterin, ethanediol and ethylene glycol (PDB entry 2bfp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Pteridine reductase (PTR) catalyzes the reduction of 5,6,7,8-tetrahydrobiopterin (THBP) to biopterin. PTR is part of pterin and folate metabolism. NADP is the hydrogen acceptor in this reduction. Relevance PTR is essential for growth of trypanosomatid protozoans like Leishmania parasites, thus PTR inhibitors like methotrexate (MTX) or triaminoquinazoline (TAQ) are tested as potential drugs. Structural highlights Six residues (colored in deepskyblue) are important for creating the active site, substrate binding or implicated in catalysis. Water molecules are shown as red spheres.

3D structures of pteridine reductase

Updated on 08-February-2022

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• Pteridine reductase
  • 2xox – LdPTR1 (mutant) – Leishmania donovani
    
  • 2bfo – LmPTR1 + NADPH – Leishmania major
    
• Pteridine reductase complex with inhibitor
  • 1e7w – LmPTR1 + NADPH + MTX
    
  • 1w0c – LmPTR1 + NADPH + TAQ
    
  • 2bfa, 2bfm, 3h4v, 5l42, 5l4n, 6rxc – LmPTR1 + NADPH + inhibitor
    
  • 1p33 – PTR1 + NADPH + MTX – Leishmania tarentolae
    
  • 1mxf – TcPTR2 + NADPH + MTX – Trypanosoma cruzi
    
  • 2c7v – TbPTR1 + NADPH + MTX – Trypanosoma brucei
    
  • 3bmn, 3bmo, 3bmq, 2wd7, 2wd8, 2vz0, 3jq6, 3jq7, 3jq8, 3jq9, 3jqa, 3jqb, 3jqc, 3jqf, 3jqd, 3jqe, 3jqg, 3gn1, 3gn2, 3mcv, 2x9g, 2x9v, 2x9n, 2yhi, 2yhu, 4cl8, 4cld, 4cle, 4clh, 4clo, 4clr, 4clx, 4cm1, 4cm3, 4cm4, 4cm5, 4cm6, 4cm7, 4cm8, 4cm9, 4cma, 4cmb, 4cmc, 4cme, 4cmg, 4cmi, 4cmj, 4cmk, 5k6a, 5izc, 5jcj, 5jcx, 5jdc, 5jdi, 4wcd, 4wcf, 6gck, 6gcl, 6gcp, 6gcq, 6gd0, 6gd4, 6gdo, 6gdp, 6gex, 6gey, 6tbx, 6rx6, 6rx5, 6rx0, 7opj – TbPTR1 + NADPH + inhibitor
    
  • 6hnc, 6hnr, 6how – TbPTR1 + NADPH + cycloguanyl derivative
    
• Pteridine reductase complex with ligand
  • 2bfp – LmPTR1 + NADPH + THBP
    
  • 2qhx – LmPTR1 + NADPH + ligand
    
  • 1e92, 2bf7 – LmPTR1 + NADPH + DHBP
    
  • 1mxh – TcPTR1 + NADPH + folate
    
  • 3bmc – TbPTR1 + NADPH + folate
    

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