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==Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor==
==Structure of Streptogramin Acetyltransferase in Complex with an Inhibitor==
<StructureSection load='3dho' size='340' side='right' caption='[[3dho]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3dho' size='340' side='right'caption='[[3dho]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dho]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DHO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dho]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DHO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B2M:6-BROMO-N-[(1Z)-(3,5-DICHLORO-2-HYDROXYPHENYL)METHYLIDENE]-2-METHYLQUINOLINE-4-CARBOHYDRAZIDE'>B2M</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2M:6-BROMO-N-[(1Z)-(3,5-DICHLORO-2-HYDROXYPHENYL)METHYLIDENE]-2-METHYLQUINOLINE-4-CARBOHYDRAZIDE'>B2M</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1khr|1khr]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1khr|1khr]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vatD, satA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vatD, satA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dho OCA], [http://pdbe.org/3dho PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dho RCSB], [http://www.ebi.ac.uk/pdbsum/3dho PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dho ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dho OCA], [https://pdbe.org/3dho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dho RCSB], [https://www.ebi.ac.uk/pdbsum/3dho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dho ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC]] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.  
[[https://www.uniprot.org/uniprot/VATD_ENTFC VATD_ENTFC]] Inactivates the A compounds of streptogramin antibiotics by acetylation, thus providing resistance to these antibiotics.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Atcc 19434]]
[[Category: Atcc 19434]]
[[Category: Large Structures]]
[[Category: Pesaresi, A]]
[[Category: Pesaresi, A]]
[[Category: Roderick, S L]]
[[Category: Roderick, S L]]
Retrieved from "https://proteopedia.org/3dho"