Plasmepsin

spinqualitylabelsall models Plasmepsin II complex with a potential antimalarial drug (PDB entry 4cku) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). Proplasmepsin II exhibits a large shift between its domains which renders the protease inactive. Relevance Plm is a potential target for anti-malaria drugs. Structural highlights The active site of Plm II contains a catalytic dyad of 2 Asp residues which interact with potential antimalarial inhibitor. Whole active site. Water molecules are shown as red spheres.

3D structures of plasmepsin

Updated on 12-February-2022

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• Histo-Aspartic Protease
  • 3fns, 3qvc, 6kub, 6kuc, 6kud – PfHAP - Plasmodium falciparum
    
  • 3fnt – PfHAP + pepstatin
    
  • 3fnu, 3qvi – PfHAP + inhibitor
    
• Plasmepsin I
  • 3qrv – PfPlm I residues 117-457
    
  • 3qs1 - PfPlm I residues 117-457 + inhibitor
• Plasmepsin II
  • 1lf4 – PfPlm II
    
  • 3f9q – PfPlm II (mutant)
    
  • 2r9b – PfPlm II + peptide inhibitor
    
  • 1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy, 4cku, 4y6m, 4z22, 5yia, 5yib, 5yic, 5yid, 5yie – PfPlm II + inhibitor
    
  • 4ya8 – PfPlm II (mutant) + inhibitor
    
  • 1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative
    
  • 1m43 - PfPlm II (mutant) + pepstatin derivative
    
• Plasmepsin IV
  • 2anl – Plm IV + statine derivative – Plasmodium malariae
    
  • 1ls5 - PfPlm IV + pepstatin derivative
    
• Plasmepsin V or aspartic protease PM5
  • 6c4g – PvPlm V + inhibitor
    
• Plasmepsin X
  • 7ry7 – PvPlm X
    
• Proplasmepsin II
  • 1pfz, 5bwy - PfProPlm II
    
  • 1miq – PvProPlm II – Plasmodium vivax
    
  • 1qs8, 5i70 - PvPlm II + pepstatin derivative
    

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