7bwq: Difference between revisions
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==Structure of nonstructural protein Nsp9 from SARS-CoV-2== | ==Structure of nonstructural protein Nsp9 from SARS-CoV-2== | ||
<StructureSection load='7bwq' size='340' side='right'caption='[[7bwq]]' scene=''> | <StructureSection load='7bwq' size='340' side='right'caption='[[7bwq]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7bwq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWQ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwq OCA], [https://pdbe.org/7bwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwq RCSB], [https://www.ebi.ac.uk/pdbsum/7bwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwq ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwq OCA], [https://pdbe.org/7bwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwq RCSB], [https://www.ebi.ac.uk/pdbsum/7bwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwq ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of a potentially fatal disease named coronavirus disease 2019 (COVID-19), has raised significant public health concerns globally. To date, the COVID-19 pandemic has caused millions of people to be infected with SARS-CoV-2 worldwide. It has been known since the 2003 SARS epidemic that coronaviruses (CoVs) have large RNA genomes, the replication of which requires an RNA-dependent RNA replication/transcription complex. CoV nonstructural proteins (Nsps) play pivotal roles in the assembly of this complex and associated enzymatic functions in virus genomic replication. Several smaller nonenzymatic Nsps assist with RNA-dependent RNA polymerase function. In this study, we determined the structure of SARS-CoV-2 nonstructural protein 9 (nsp9), an RNA-binding protein that is essential for CoV replication. Its homotetrameric structure with two stable dimeric interfaces provids a structural basis for understanding the mechanisms of RNA-binding protein self-assembly, which may be essential for the regulation of viral RNA replication and transcription. | |||
Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2.,Zhang C, Chen Y, Li L, Yang Y, He J, Chen C, Su D Mol Biomed. 2020 Aug 20;1(1):5. doi: 10.1186/s43556-020-00005-0. PMID:35006420<ref>PMID:35006420</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7bwq" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: 2019-ncov]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen Y]] | [[Category: Chen, Y]] | ||
[[Category: Li L]] | [[Category: Li, L]] | ||
[[Category: Su D]] | [[Category: Su, D]] | ||
[[Category: Zhang C]] | [[Category: Zhang, C]] | ||
[[Category: Nsp9]] | |||
[[Category: Sars-cov-2]] | |||
[[Category: Structural protein]] | |||
