SecA: Difference between revisions

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=Introduction=

The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' or '''~~protein~~ translocase subunit SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PBD motions]].

The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' or '''preprotein translocase subunit SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> . For additional details see [[SecA PBD motions]].

=Structure=

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 <StructureSection load='3jv2' size='350' side='right' scene='' caption='Dimer of monomeric SecA complex with peptide (pink and yellow), ADP and Mg+2 ion (green), [[3jv2]]' pspeed='8'>
 =Introduction=
-The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' or '''protein translocase subunit SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> .  For additional details see [[SecA PBD motions]].
+The [http://www.nature.com/nature/journal/v455/n7215/full/nature07335.html SecA] ATPase '''SecA''' or '''preprotein translocase subunit SecA''' drives the post-translational translocation of proteins through the SecY channel in the bacterial inner membrane. SecA is a dimer that can dissociate into monomers under certain conditions. Many bacterial proteins are transported post-translationally across the inner membrane by the Sec machinery, which consists of two essential components (1-4). One is the SecY complex, which forms a conserved heterotrimeric protein-conducting channel in the inner membrane.<ref name=journal1>PMID:15618215</ref> The other is SecA, a cytoplasmic ATPase, which "pushes" substrate polypeptide chains through the SecY channel.<ref name=journal1/> .  For additional details see [[SecA PBD motions]].
 =Structure=