7wh0: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==structure of C elegans BCMO-1== | ==structure of C elegans BCMO-1== | ||
<StructureSection load='7wh0' size='340' side='right'caption='[[7wh0]]' scene=''> | <StructureSection load='7wh0' size='340' side='right'caption='[[7wh0]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WH0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wh0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WH0 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wh0 OCA], [https://pdbe.org/7wh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7wh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wh0 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OXD:OXALIC+ACID'>OXD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wh0 OCA], [https://pdbe.org/7wh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7wh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wh0 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as beta-carotene 15,15'-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO-1 and BCMO-2 remains uncharacterized. Sequence homology indicates that the two enzymes belong to the carotenoid cleavage dioxygenase family that share a seven-bladed beta-propeller fold with a nonheme iron center. Here we determined crystal structures of BCMO-1 and BCMO-2 at resolutions of 1.8 and 1.9 A, respectively. Structural analysis reveals that BCMO-1 and BCMO-2 are strikingly similar to each other. We also characterized their beta-carotene cleavage activity, but the results suggest that they may not act as beta-carotene 15,15'-oxygenases. | |||
Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans.,Pan W, Zhou YL, Wang J, Dai HE, Wang X, Liu L Front Mol Biosci. 2022 Feb 10;9:844453. doi: 10.3389/fmolb.2022.844453., eCollection 2022. PMID:35223999<ref>PMID:35223999</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7wh0" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Liu L]] | [[Category: Liu, L]] | ||
[[Category: Pan W]] | [[Category: Pan, W]] | ||
[[Category: Beta-carotene]] | |||
[[Category: Caenorhabditis elegan]] | |||
[[Category: Dioxygenase]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Nonheme iron]] | |||
[[Category: Retinoid]] | |||
