3h87: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:


==Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis==
==Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis==
<StructureSection load='3h87' size='340' side='right' caption='[[3h87]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
<StructureSection load='3h87' size='340' side='right'caption='[[3h87]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3h87]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H87 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H87 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3h87]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H87 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0314, Rv0301 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), Rv0300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0314, Rv0301 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), Rv0300 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h87 OCA], [http://pdbe.org/3h87 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h87 RCSB], [http://www.ebi.ac.uk/pdbsum/3h87 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h87 ProSAT], [http://www.topsan.org/Proteins/ISFI/3h87 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h87 OCA], [https://pdbe.org/3h87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h87 RCSB], [https://www.ebi.ac.uk/pdbsum/3h87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h87 ProSAT], [https://www.topsan.org/Proteins/ISFI/3h87 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VAPC2_MYCTO VAPC2_MYCTO]] Toxic component of a toxin-antitoxin (TA) module. Acts as an RNase. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2 (By similarity). [[http://www.uniprot.org/uniprot/VAPB2_MYCTU VAPB2_MYCTU]] Antitoxin component of a type II toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the antitoxin may obstruct the toxin's RNA-binding groove, blocking access to the active sites. Additionally, the C-terminal arginine of the antitoxin may remove Mg(2+) ions from the toxin active sites.<ref>PMID:20011113</ref> <ref>PMID:23011806</ref> <ref>PMID:15718296</ref>   
[[https://www.uniprot.org/uniprot/VAPC2_MYCTO VAPC2_MYCTO]] Toxic component of a toxin-antitoxin (TA) module. Acts as an RNase. All its toxic effects are neutralized by coexpression with cognate antitoxin VapB2 (By similarity). [[https://www.uniprot.org/uniprot/VAPB2_MYCTU VAPB2_MYCTU]] Antitoxin component of a type II toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the antitoxin may obstruct the toxin's RNA-binding groove, blocking access to the active sites. Additionally, the C-terminal arginine of the antitoxin may remove Mg(2+) ions from the toxin active sites.<ref>PMID:20011113</ref> <ref>PMID:23011806</ref> <ref>PMID:15718296</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h87_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h87_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
Line 33: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Myctu]]
[[Category: Cascio, D]]
[[Category: Cascio, D]]
Retrieved from "https://proteopedia.org/3h87"