Shikimate kinase

spinqualitylabelsall models Shikimate kinase complex with shikimate and ADP 2dfn Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Shikimate kinase (SK) catalyzes the ATP-dependent phosphorylation of shikimate to produce shikimate 3-phosphate. It is part of the plant and bacteria pathway of synthesizing aromatic acids. Relevance SK inhibitors can be used as antimicrobial drugs. Structural highlights The active site of SK contains the substrate shikimate and an ADP molecule. ADP binding site. Water molecules are shown as red spheres. Whole binding site. 3D Structures of shikimate kinase Shikimate kinase 3D structures Updated on 21-March-2022 {"openlevels":0} Shikimate kinase 2g1j, 2iyt – MtSK – Mycobacterium tuberculosis 2pt5 – SK – Aquifex aeolicus 3nwj – SK – Arabidopsis thaliana 3trf – SK – Coxiella burnetii 3vaa – SK – Bacterioides thetaiotaomicron 1via – SK – Campylobacter jejuni 1zuh, 3hr7 – HpSK – Helicobacter pylori 3mrs – HpSK (mutant) 1shk – EchSK – Erwinia chrysanthemi 1e6c – EchSK (mutant) 1kag – SK – Escherichia coli Shikimate kinase binary complex 1l4u, 1l4y, 1u8a, 2iyu, 2iyv, 2dft – MtSK + ADP 2iyw – MtSK + ATP 3baf – MtSK + AMPPNP 2shk – EchSK + ADP 1zui – HpSK + shikimate 3n2e – HpSK (mutant) + inhibitor 2g1k, 2iyr, 2iys, 2iyx – MtSK + shikimate 2iyy – MtSK + shikimate-3-phosphate 4y0a – SK + shikimate – Acinetobacter baumannii Shikimate kinase ternary complex 2iyz, 4bqs – MtSK + ADP + shikimate-3-phosphate 1we2, 2dfn, 2iyq – MtSK + ADP + shikimate 1zyu – MtSK + AMPPCP + shikimate 3muf – HpSK + ADP + shikimate-3-phosphate

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