Sandbox Reserved 1705: Difference between revisions

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== General Structure ==

Anaplastic lymphoma kinase is a <scene name='90/904310/Dimer/2'>homodimer</scene>, each monomer consisting of seven domains and two regions <ref name="Tongqing">PMID:34819665</ref>. These domains and regions are as follows: N-terminal region (NTR), two meprin–A-5 protein–receptor protein tyrosine phosphatase μ domains (MAM), low density lipoprotein receptor class A domain (LDL), tumor necrosis factor receptor-like domain (TNF), glycine rich region (GlyR), epidermal growth factor receptor-like domain (EGF), transmembrane α-helix (TMH), kinase domain <ref name="Reshetnyak">PMID:34819673</ref>. The structures of the N-terminal region, MAM, and LDL have not been determined. The glycine rich region is a part of the TNF domain. Only the TNF, GlyR, and EGF portions of ALK are required for ligand binding. All portions of anaplastic lymphoma kinase are located in the extracellular domain except for the transmembrane α-helix which is in the transmembrane region and the kinase domain that is located in the intracellular domain. [[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]

Anaplastic lymphoma kinase is a <scene name='90/904310/Dimer/2'>homodimer</scene>, each monomer consisting of seven domains and two regions <ref name="Tongqing">PMID:34819665</ref>. These domains and regions are as follows: N-terminal region (NTR), two meprin–A-5 protein–receptor protein tyrosine phosphatase μ domains (MAM), low density lipoprotein receptor class A domain (LDL), <scene name='90/904310/Tnf_highlighted_monomer/2'>tumor necrosis factor receptor-like domain</scene> (TNF), <scene name='90/904310/Glyr_highlighted_monomer/1'>glycine rich region</scene>(GlyR), epidermal growth factor receptor-like domain (EGF), transmembrane α-helix (TMH), kinase domain <ref name="Reshetnyak">PMID:34819673</ref>. The structures of the N-terminal region, MAM, and LDL have not been determined. The glycine rich region is a part of the TNF domain. Only the TNF, GlyR, and EGF portions of ALK are required for ligand binding. All portions of anaplastic lymphoma kinase are located in the extracellular domain except for the transmembrane α-helix which is in the transmembrane region and the kinase domain that is located in the intracellular domain. [[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]

=== Ligand Binding===

Sandbox Reserved 1705: Difference between revisions

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 == General Structure ==
-Anaplastic lymphoma kinase is a <scene name='90/904310/Dimer/2'>homodimer</scene>, each monomer consisting of seven domains and two regions <ref name="Tongqing">PMID:34819665</ref>. These domains and regions are as follows: N-terminal region (NTR), two meprin–A-5 protein–receptor protein tyrosine phosphatase μ domains (MAM), low density lipoprotein receptor class A domain (LDL), tumor necrosis factor receptor-like domain (TNF), glycine rich region (GlyR), epidermal growth factor receptor-like domain (EGF), transmembrane α-helix (TMH), kinase domain <ref name="Reshetnyak">PMID:34819673</ref>. The structures of the N-terminal region, MAM, and LDL have not been determined. The glycine rich region is a part of the TNF domain. Only the TNF, GlyR, and EGF portions of ALK are required for ligand binding. All portions of anaplastic lymphoma kinase are located in the extracellular domain except for the transmembrane α-helix which is in the transmembrane region and the kinase domain that is located in the intracellular domain. [[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]
+Anaplastic lymphoma kinase is a <scene name='90/904310/Dimer/2'>homodimer</scene>, each monomer consisting of seven domains and two regions <ref name="Tongqing">PMID:34819665</ref>. These domains and regions are as follows: N-terminal region (NTR), two meprin–A-5 protein–receptor protein tyrosine phosphatase μ domains (MAM), low density lipoprotein receptor class A domain (LDL), <scene name='90/904310/Tnf_highlighted_monomer/2'>tumor necrosis factor receptor-like domain</scene> (TNF), <scene name='90/904310/Glyr_highlighted_monomer/1'>glycine rich region</scene>(GlyR), epidermal growth factor receptor-like domain (EGF), transmembrane α-helix (TMH), kinase domain <ref name="Reshetnyak">PMID:34819673</ref>. The structures of the N-terminal region, MAM, and LDL have not been determined. The glycine rich region is a part of the TNF domain. Only the TNF, GlyR, and EGF portions of ALK are required for ligand binding. All portions of anaplastic lymphoma kinase are located in the extracellular domain except for the transmembrane α-helix which is in the transmembrane region and the kinase domain that is located in the intracellular domain. [[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]
 === Ligand Binding===