Sandbox Reserved 1705: Difference between revisions
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==== Tyrosine Phosphorylation Mechanism ==== | ==== Tyrosine Phosphorylation Mechanism ==== | ||
Dimerization of anaplastic lymphoma kinase activates the kinase domains of each monomer. Next, the kinase domains phosphorylate the tyrosine residues of the opposite monomer using ATP. These phosphorylated tyrosine residues recruit signal proteins through phosphorylation. These signal proteins begin a signaling cascade through utilizing various signal pathways. These pathways signal for cell proliferation and survival (ex: begin transcription). [[Image:Tyrosine_Mechanism_Picture.png|350 px|right|thumb|Figure 1. Tyrosine phosphorylation mechanism]] | Dimerization of anaplastic lymphoma kinase activates the kinase domains of each monomer. Next, the kinase domains phosphorylate the tyrosine residues of the opposite monomer using ATP. These phosphorylated tyrosine residues recruit signal proteins through phosphorylation. These signal proteins begin a signaling cascade through utilizing various signal pathways. These pathways signal for cell proliferation and survival (ex: begin transcription). [[Image:Tyrosine_Mechanism_Picture.png|350 px|right|thumb|Figure 1. Tyrosine phosphorylation mechanism]] | ||
== Applications == | == Applications == | ||
