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==Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB==
==Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB==
<StructureSection load='5zk3' size='340' side='right' caption='[[5zk3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5zk3' size='340' side='right'caption='[[5zk3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZK3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZK3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QNB:(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL+HYDROXY(DIPHENYL)ACETATE'>QNB</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QNB:(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL+HYDROXY(DIPHENYL)ACETATE'>QNB</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xba|5xba]], [[5xbb|5xbb]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5xba|5xba]], [[5xbb|5xbb]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk3 OCA], [http://pdbe.org/5zk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zk3 RCSB], [http://www.ebi.ac.uk/pdbsum/5zk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zk3 OCA], [https://pdbe.org/5zk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zk3 RCSB], [https://www.ebi.ac.uk/pdbsum/5zk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zk3 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.  
[[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5zk3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5zk3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Bacillus coli migula 1895]]
[[Category: Large Structures]]
[[Category: Hirata, K]]
[[Category: Hirata, K]]
[[Category: Horita, S]]
[[Category: Horita, S]]
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