Neurofibromin: Difference between revisions
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<StructureSection load='' scene='90/904325/Introductory_image_full/1' size='340' side='right' caption='Neurofibromin'> | <StructureSection load='' scene='90/904325/Introductory_image_full/1' size='340' side='right' caption='Neurofibromin'> | ||
== Introduction == | == Introduction == | ||
Neurofibromin is a cytoplasmic protein located close to the cell membrane that is encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. It is a suppressor of the Ras oncogene through its effect on the rate of catalysis from Ras-GTP (active) to Ras-GDP (inactive)<ref name= ''Hall''>PMID:12213964</ref>. NF increasing the rate of catalysis of Ras means that Ras spends more time in its inactive state and cannot cause unnecessary cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>. | |||
== Structure == | == Structure == | ||
===Domains=== | ===Domains=== | ||
