Sandbox Reserved 1713: Difference between revisions
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The negatively charged phosphate groups on the cell membrane interact with the highly conserved positively charged residues on ALKAL ligand that face the membrane, which stabilizes the ligand to bind to ALK even better. <ref>DOI: 10.1038/s41586-021-04140-8</ref> | The negatively charged phosphate groups on the cell membrane interact with the highly conserved positively charged residues on ALKAL ligand that face the membrane, which stabilizes the ligand to bind to ALK even better. <ref>DOI: 10.1038/s41586-021-04140-8</ref> | ||
== Disease == | == Disease == | ||
There are many mutations that could take place causing constitutive receptor activation, enhancement between the interaction of receptors or stabilization of active receptors are known to relate to oncogenic potentials. | |||
<scene name='90/904318/Premutationresidues/2'>mutated residues</scene> | <scene name='90/904318/Premutationresidues/2'>mutated residues</scene> | ||
<scene name='90/904318/His694/2'>His694</scene> | <scene name='90/904318/His694/2'>His694</scene> | ||
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<ref>DOI: 10.1038/s41586-021-03959-5</ref> | <ref>DOI: 10.1038/s41586-021-03959-5</ref> | ||
<ref>DOI: 10.1038/s41586-021-04141-7</ref> | <ref>DOI: 10.1038/s41586-021-04141-7</ref> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
