Sandbox Reserved 1709: Difference between revisions
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<scene name='90/904314/Cap_Domain/1'>VKOR Cap Domain</scene> | <scene name='90/904314/Cap_Domain/1'>VKOR Cap Domain</scene> | ||
Closed conformation | Closed conformation | ||
A key part of VKOR is the function of the cap domain in activating Vitamin K, as it induces the structural change of the open conformation to the closed conformation when the substrate binds. This initiates a domino effect through the [https://reader.elsevier.com/reader/sd/pii/S0021925820001386?token=9F8E1964241D20488CA55E035D35D9A5D650A7B3FDAD9A5579598A8DC00127539BE71CF1785B117102144AC1F41ABB6C&originRegion=us-east-1&originCreation=20220329001707/ catalytic mechanism]. The cap domain has critical interactions that stabilize the closed conformation including disulfide bridges and polar interactions of amino acids that keep the cap and beta hairpin closed while Vitamin K is activated. | |||
<scene name='90/904314/Disulfide_bridge_stabilization/1'>Disulfide Bridge Stabilization</scene> | <scene name='90/904314/Disulfide_bridge_stabilization/1'>Disulfide Bridge Stabilization</scene> | ||
