Sandbox Reserved 1706: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Levi Hrabos (talk | contribs) No edit summary |
Levi Hrabos (talk | contribs) No edit summary |
||
| Line 51: | Line 51: | ||
Mutations to NF1 in the critical interaction involved in the GRD active site with R1276, structurally and functionally prove why they can cause cancer, as Ras is no longer mediated. The importance of this residue when binding to Ras may be able to contribute to future studies in potentially mimicking this arginine finger when bound to Ras, in cases where mutations would impact R1276 in its normal function. Observing the nature of NF1 can further drug development and further improve what is already known about NF1.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Kioro"> DOI:10.1038/labinvest.2016.142</ref><ref name="Sabatini"> DOI:10.1007/s11940-015-0355-4</ref> | Mutations to NF1 in the critical interaction involved in the GRD active site with R1276, structurally and functionally prove why they can cause cancer, as Ras is no longer mediated. The importance of this residue when binding to Ras may be able to contribute to future studies in potentially mimicking this arginine finger when bound to Ras, in cases where mutations would impact R1276 in its normal function. Observing the nature of NF1 can further drug development and further improve what is already known about NF1.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Kioro"> DOI:10.1038/labinvest.2016.142</ref><ref name="Sabatini"> DOI:10.1007/s11940-015-0355-4</ref> | ||
==References placeholders== | ==References placeholders== | ||
This section will be removed it is just for copy and | This section will be removed it is just for copy and paste purposes. We will add the PDB code names as references in the captions of each scene. | ||
<ref name="Bergoug"> DOI:10.3390/cells9112365</ref> | <ref name="Bergoug"> DOI:10.3390/cells9112365</ref> | ||
<ref name="Bourne"> DOI:10.1038/39470</ref> | <ref name="Bourne"> DOI:10.1038/39470</ref> | ||
