Sandbox Reserved 1709: Difference between revisions

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Since activated Vitamin K plays a crucial role in blood coagulation in the body, any defects in the function and enzymatic activity of VKOR may have detrimental effects on Vitamin K's ability to promote important blood clotting. Ultimately, mutations in VKOR may lead to increased susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K has also been shown to have an important role in maintaining bone health, so inactivity of VKOR could also be linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].

=== Inhibition ===

The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/1'> Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.

The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/2'>Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.

=== Mutations ===

Sandbox Reserved 1709: Difference between revisions

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@@ Line 36: / Line 36: @@
 Since activated Vitamin K plays a crucial role in blood coagulation in the body, any defects in the function and enzymatic activity of VKOR may have detrimental effects on Vitamin K's ability to promote important blood clotting. Ultimately, mutations in VKOR may lead to increased susceptibility to vascular diseases, such as a stroke [https://doi.org/10.1161/CIRCULATIONAHA.105.580167]. Vitamin K has also been shown to have an important role in maintaining bone health, so inactivity of VKOR could also be linked to decreased bone density and osteoporosis [https://doi.org/10.7759/cureus.10816].
 === Inhibition ===
-The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/1'> Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.
+The most inexpensive and common way to treat blood clotting is through the VKOR inhibitor, <scene name='90/906893/Vkor_with_warfarin_bound/2'>Warfarin</scene>. [https://en.wikipedia.org/wiki/Warfarin Warfarin] is able to do so by outcompeting KO, such that Vitamin K cannot be activated to promote coagulation in the blood. Warfarin will enter the binding pocket of VKOR, creating strong hydrogen bonds with the active site. Warfarin resistance may also occur due to mutations of VKOR, decreasing the effective anticoagulation some drugs may be attempting to promote. The degree of resistance is important to determine so that warfarin may be an effective anticoagulant without being detrimentally effective in blood flow.
 === Mutations ===