Sandbox Reserved 1710: Difference between revisions

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== Structure ==

Neurofibromin is a <scene name='90/904315/Homodimer/3'>homodimer</scene> made up of two identical chains. There are two conformations that classify neurofibromin known as its open and closed conformations. These conformations allow neurofibromin to associate with the protein Ras and perform its function of Ras regulation. The transformation between the overall closed conformation and open conformation of neurofibromin signifies a transition between an active neurofibromin protein and an inactive neurofibromin protein. There are two important domains involved in the transition between the open and closed conformations, the <scene name='90/905640/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/2'>Sec14-PH</scene> domain. Although neurofibromin is a homodimer with two identical protomers, only one protomer needs to have its GRD and Sec14-PH domains rotated in the open conformation in order for it to be able to perform its function.

Neurofibromin is a <scene name='90/904315/Homodimer/3'>homodimer</scene> made up of two identical chains. There are two conformations that classify neurofibromin known as its open and closed conformations. These conformations allow neurofibromin to associate with the protein Ras and perform its function of Ras regulation. The transformation between the overall closed conformation and open conformation of neurofibromin signifies a transition between an active neurofibromin protein and an inactive neurofibromin protein. There are two important domains involved in the transition between the open and closed conformations, the <scene name='90/905640/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/2'>Sec14-PH</scene> domain (observed here in the closed conformation). Although neurofibromin is a homodimer with two identical protomers, only one protomer needs to have its GRD and Sec14-PH domains rotated in the open conformation in order for it to be able to perform its function.

=== Closed Conformation ===

Sandbox Reserved 1710: Difference between revisions

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 == Structure ==
-Neurofibromin is a <scene name='90/904315/Homodimer/3'>homodimer</scene> made up of two identical chains. There are two conformations that classify neurofibromin known as its open and closed conformations. These conformations allow neurofibromin to associate with the protein Ras and perform its function of Ras regulation. The transformation between the overall closed conformation and open conformation of neurofibromin signifies a transition between an active neurofibromin protein and an inactive neurofibromin protein. There are two important domains involved in the transition between the open and closed conformations, the <scene name='90/905640/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/2'>Sec14-PH</scene> domain. Although neurofibromin is a homodimer with two identical protomers, only one protomer needs to have its GRD and Sec14-PH domains rotated in the open conformation in order for it to be able to perform its function.
+Neurofibromin is a <scene name='90/904315/Homodimer/3'>homodimer</scene> made up of two identical chains. There are two conformations that classify neurofibromin known as its open and closed conformations. These conformations allow neurofibromin to associate with the protein Ras and perform its function of Ras regulation. The transformation between the overall closed conformation and open conformation of neurofibromin signifies a transition between an active neurofibromin protein and an inactive neurofibromin protein. There are two important domains involved in the transition between the open and closed conformations, the <scene name='90/905640/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/2'>Sec14-PH</scene> domain (observed here in the closed conformation). Although neurofibromin is a homodimer with two identical protomers, only one protomer needs to have its GRD and Sec14-PH domains rotated in the open conformation in order for it to be able to perform its function.
 === Closed Conformation ===