2vx9: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2vx9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX9 OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VX9 FirstGlance].

<table><tr><td colspan='2'>[[2vx9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2VX9 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vx9 OCA], [~~http~~://pdbe.org/2vx9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vx9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vx9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vx9 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2vx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vx9 OCA], [https://pdbe.org/2vx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vx9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vx9 ProSAT]</td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3]] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref>

[[https://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3]] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='2vx9' size='340' side='right'caption='[[2vx9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vx9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VX9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vx9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VX9 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vx9 OCA], [http://pdbe.org/2vx9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vx9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vx9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vx9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vx9 OCA], [https://pdbe.org/2vx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vx9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vx9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3]] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref>
+[[https://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3]] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]